Salmon DNA for skin is a facial treatment originating in Korean cosmetics and aesthetic medicine, popular in beauty and dermatology clinics. This technology has spread to other Asian countries and has gained global popularity in recent years thanks to testimonials about its benefits in skin regeneration.
Salmon DNA in aesthetics: origin and benefits
According to the article: “First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide“, PDRN (Polydeoxyribonucleotide) is a linear polymer of DNA, typically derived from the gonads of salmon trout (reason why it is commonly called salmon DNA). PDRN has been shown to be effective in promoting wound healing, tissue regeneration, and reducing inflammation, as well as regulating cytokine signaling pathways involved in collagen production.
Additionally, PDRN is known to enhance corneal epithelial regeneration and alleviate pain and disability in patients with rotator cuff disease. It also improves wound closure and promotes re-epithelialization in patients with refractory diabetic foot ulcers, being particularly effective in skin wound regeneration. PDRN stimulates wound healing by acting as a growth promoter and chemokine, promoting the proliferation of epithelial cells at the wound site.

South Korea is a pioneer in the use of PDRN (Polydeoxyribonucleotide), the active ingredient extracted from salmon DNA, applied in both dermatological treatments and facial aesthetics. Initially, PDRN was used in regenerative medicine to accelerate wound healing, regenerate damaged tissue, and treat burns. After its effects on cell renewal and skin improvement were proven, it began to be used in Korean aesthetic clinics, giving rise to the well-known Rejuran Healer treatment (salmon DNA injections), from which non-invasive topical versions for facial treatment are derived.
Benefits of Salmon DNA for skin
In the USA, the topical use of salmon DNA is permitted, especially in combination with microneedling or laser, as it is considered a cosmetic ingredient or additive to aesthetic procedures. The benefits are:
- Cell Regeneration: PDRN stimulates tissue repair and collagen production.
- Elasticity Improvement: Increases firmness and reduces sagging.
- Antioxidant Effect: Protects skin from environmental damage.
- Deep Hydration: Helps retain moisture in the skin.
- Wrinkle Reduction: Improves texture and smooths fine lines.
- Anti-inflammatory Effect: Soothes skin after procedures such as laser or microneedling.
Salmon DNA for skin care is used because salmon sperm is especially rich in pure, high-quality DNA, its molecular structure is highly compatible with regenerative processes in humans; and, importantly, it has a low likelihood of causing allergies or rejection because it is a non-cellular, highly purified genetic material.
Who is it recommended for?
Salmon DNA skin treatment is safe, as salmon DNA is highly biocompatible with the human body and has a low risk of allergic reaction. However, it should be performed by trained professionals.
The Salmon DNA skin treatment is called Salmon DNA Facial at aesthetic clinics. This treatment is recommended for:
- People with signs of aging (fine lines, loss of elasticity)
- Sun-damaged skin
- People with minor scarring or dull skin
- Post-aesthetic procedures to accelerate skin regeneration
Main aesthetic procedures where salmon DNA for skin is used:
Microneedling: Salmon DNA is applied in serum form after microneedling to enhance cell regeneration and improve absorption.
Faciales regenerativos: It is used in massages, masks or with equipment (ultrasound, electroporation) to hydrate and repair the skin.
Post-laser or peeling: Ayuda a acelerar la cicatrización, calmar la piel y reducir la inflamación después de láser o peelings químicos.
Scar treatments: Improves tissue regeneration and reduces marks or minor scars..
Facial mesotherapy: It is combined with vitamins and other active ingredients to achieve an overall revitalizing effect.
Tratamientos antiaging en cuello y escote: Helps improve firmness and elasticity in these delicate areas.
Salmon DNA facial
The Salmon DNA Facial is one of the most innovative treatments in skincare.
Deep hydration | Elasticity | Cell repair
Whether as a post-cosmetic procedure or to look better, if you’re interested in applying salmon ADN for skin, schedule an appointment now.
A facial aesthetics professional will be happy to assist you.
*You can pay for your procedure before the session, click here
